This study was designed to examine efficacy of separate and combined protocols for obesity reduction with sequential outcomes after one year. This was an experimental case vs control study, lasting 12 months, conducted from 2018 to 2020.Methods: Ninety-four obese subjects, ages 14-76 with Body Mass Index (BMI) > 30, enrolled in this multi-center study in Texas, USA. Treatments included food allergen identification/elimination (ALCAT, leukocyte reaction test which showed reactions to 237 foods) and/or a brief, aerobic-surge exercise (2-minute sessions, 5/day). Foods with significant reaction for each subject were eliminated from their diet for 12 months (mean 36 foods/subject).Subject categorization was as follows: Group 1 Combined Food Allergen Elimination and Aerobic-surge exercise (N=23); Group 2 Food Allergen Elimination alone (N=23); Group 3 Aerobic-surge exercise alone (N=18); Group 4 was the Control group who chose no treatments (N=30). The dependent variables included changes in weight, BMI, and waist circumference.