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Comprehensive testing for methylation and detoxification

The MethylDetox Profile gives more actionable information than MTHFR testing alone, giving you a more complete picture of your body’s methylation and detoxification. The MethylDetox profile includes Smart Commentaries, detailing recommended nutrients based on your genetics.

Standard MTHFR genotyping only evaluates folic acid metabolism. Scientific research reveals that a variety of genes are involved in maintaining methionine/homocysteine balance. Genetic variations (SNPs) in these important genes influence your methylation potential. Individual methylation is monitored using homocysteine levels. Important SNPs are included to evaluate your ability to methylate neurotransmitters, DNA and toxins.

Who may benefit from this test?

Individuals with any of the following diagnoses or symptoms, lab data indicating the tendency toward:

  • Cardiovascular Diseases e.g. hypertension, coronary artery disease, stroke 4-10
  • Neurological Disorders e.g. depression, dementia, Alzheimer’s disease, ADD/ADHD, ASD, chronic fatigue syndrome, migraine, insomnia 7, 10-17
  • Metabolic Conditions e.g. metabolic syndrome, diabetes mellitus, kidney diseases, reduced ability to metabolize medications, multiple chemical sensitivity 10, 18-21
  • Musculoskeletal Disorders e.g. osteoporosis 10, 22
  • Eye Diseases e.g. macular degeneration 23, 24
  • Cancer e.g. colorectal, breast, and others 1, 10, 25

Test components

1. MTHFR

The MTHFR gene’s purpose is to produce the important MTHFR enzyme in the body. This enzyme is an important part of maintaining optimal health. If the MTHFR gene has a mutation, folate metabolism can be negatively impacted. Improper folate metabolism is implicated in many different diseases. 5, 6, 10, 26-29

2. MTR

MTR codes for the enzyme, methionine synthase (MS). MS converts homocysteine to methionine using methylated vitamin B12. Mutations in this gene significantly impact homocysteine metabolism, which can increase the risk for a number of chronic conditions such as cardiovascular diseases, metabolic and neurological conditions and certain cancers. 30

3. MTRR

The MTRR gene codes for the important enzyme, methionine synthase reductase (MSR). Methionine synthase reductase is required for the proper function of methionine synthase (see MTR). Both genes act together to convert homocysteine to methionine. Mutations can be involved with the development of cancers, Parkinson’s disease, depression, hypertension and many others. 31-36

4. COMT

COMT is the major gene involved in methylation. It plays an important role in a variety of disorders, including estrogen-induced cancers, Parkinson’s disease, depression, hypertension and many others. COMT is also necessary for maintaining the proper balance of neurotransmitters with SAMe obtained from methionine. Genetic mutations in COMT can result in various neurological problems and has also been associated with Autism. 31-36

5. AHCY

AHCY is the only enzyme known to convert S-Adenosylhomocysteine (AdoHcy) to homocysteine. It is crucial that AHCY immediately converts AdoHcy to homocysteine and adenine in order to maintain optimal methylation potential. Studies show a link between mutations in this gene with poor methylation potential and severe myopathies, developmental delays and hypermethioninemia.

6. Homocysteine

Homocysteine is an amino acid that is involved in maintaining the methionine cycle. Elevated homocysteine levels are well known risk factors for chronic disease, particularly cardiovascular, diabetes and neurodegenerative disorders 7, 10, 37

Test results

Test results include Smart Commentaries created by clinicians and scientists. Smart Commentaries include personalized recommendations for diet and nutrition supplementation.

About our lab

Cell Science Systems, Corp. is a specialty clinical laboratory that develops and performs laboratory testing in immunology and cell bioligy supporting the personalized treatment and prevention of chronic disease. Cell Science Systems, Corp. operates a CLIA certified laboratory and is an FDA inspected and registered, cGMP medical device manufacturer meeting ISO EN13485 2012 standards. 3, 17-19

Committed to quality

Cell Science Systems fulfills high quality standards in accordance with state, federal and international regulations.

  • CLIA-ID#10D0283906
  • CE Marked. TUV Certified and safety monitored
  • Supported by the EU and the State of Brandenburg
  • ISO 13485:2003 + AC:2012

Literature

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29 Ulvik A, Ueland PM, Fredriksen A, Meyer K, Vollset SE, Hoff G, Schneede J. Functional inference of the methylenetetrahydrofolate reductase 677C > T and 1298A > C polymorphisms from a large-scale epidemiological study. Hum Genet. 2007 Mar;121(1):57-64.

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33 Åberg E, Fandiño-Losada A, Sjöholm LK, Forsell Y, Lavebratt C. The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with depression and motivation in men from a Swedish population-based study. J Affect Disord. 2011 Mar;129(1-3):158-66.

34 Htun NC, Miyaki K, Song Y, Ikeda S, Shimbo T, Muramatsu M. Association of the catechol-O-methyl transferase gene Val158Met polymorphism with blood pressure and prevalence of hypertension: interaction with dietary energy intake. Am J Hypertens. 2011 Sep;24(9):1022-6.

35 Schalinske KL, Smazal AL. Homocysteine Imbalance: a Pathological Metabolic Marker. Adv Nutr Nov 2012 Adv Nutr vol. 3:755-762, 2012.

36 Ziegler DA, Ashourian P, Wonderlick JS, Sarokhan AK, Prelec D, Scherzer CR, Corkin S. Motor impulsivity in Parkinson disease: associations with COMT and DRD2 polymorphisms. Scand J Psychol. 2014 Jun;55(3):278-86.

37 Jacques PF, Rosenberg IH, et al. Serum total homocysteine concentrations in adolescent and adult Americans:results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 1999;69:482-489.